Are you aware of ConsumerLabs.com, a phenomenal subscription resource for summaries of the literature on every imaginable supplement and evaluations by quality & brand of many products? Whenever a doctor suggests a supplement to me, it’s the first place I go.
If you don’t have access to it, could I gift you a one year subscription, which I think would be helpful in your research?
I am wondering if there'd be any significant changes to the protocol if one can't access paxlovid (E.g. use nattokinase from day 1?) Paxlovid is out of reach for most of us in Europe unfortunately. Also curious what you think of the claims that curcumin, quercetin resveratrol have 3CLpro-inhibition effects/can they be added when using this protocol?
Thanks once again for an amazing article. I had tried Lactoferrin previously for LC and thought I would try again after reading this. I split one Jarrow tablet contents into 2 does, had am dose mixed with lecithin and got mild gut issues. Had the other half dose before sleep, and unfortunately it worsened the adrenaline rush I get before sleep to the point I couldn't get to sleep til 3 am.(took at 10.30). Every time I got close to dropping off a surge would wake me up. This happens often but I can usually get past it with breathing exercises. I wonder why this would happen with the Lactoferrin? I also took ferrous sulphate an hour before and 2 Boluoke Lumbrokinase at same time. I also got mild gut pain with this dose too. Is this to be expected? Huge fan of your work and follow all your posts. Thank you so much for taking the time to write them.
The 26,508 SARS-CoV-2 positive patients were predominantly male (89%) and White (59%), and 82% were overweight/obese. Medications associated with decreased 30-day mortality risk included the following: metformin (aRR, 0.33; 95% CI, 0.25–0.43), colchicine, angiotensin-converting-enzyme inhibitors (ACEi), angiotensin II receptor blockers, statins, vitamin D, antihistamines, alpha-blockers, anti-androgens, and nonsteroidal anti-inflammatory drugs (aRR, 0.69; 95% CI, 0.61–0.78). The effect of co-prescribed medications on 30-day mortality risk revealed the lowest risk for combined statins and metformin (aRR, 0.21; 95% CI, 0.15–0.31), followed by ACEi and statins (aRR, 0.25; 95% CI, 0.18–0.35), ACEi and metformin (aRR, 0.26; 95% CI, 0.17–0.40), antihistamines and NSAIDs (aRR, 0.41; 95% CI, 0.32–0.52), and in men, combined alpha-blockers and anti-androgens (aRR, 0.51; 95% CI, 0.42–0.64).
Conclusions
In this large national cohort, treatment of SARS-CoV-2 positive patients with individual or co-prescribed metformin and statins, ACEi and statins (or metformin) and other medications was associated with a markedly decreased 30-day mortality and can likely be continued safely. Clinical trials may assess their therapeutic benefit.
Would taking famatodine reduce the effects on stomach acid on lactoferrin therefore increasing efficacy? I see this trial proposed the combination but I can’t find any articles on the outcome.
Thank you for this detailed and extensive post. I would add one caveat. Diphenhydramine is anticholinergic. Its most dramatic potential side effects are more likely in older age groups. People age 65 and above are often advised not to take anticholingeric medications. That includes a great many antihistamines and decongestants. (I don't have your background. I know this only because it's why I had to reluctantly discontinue a daily antihistamine.)
This is excellent thanks. Any thoughts on extra suggestions below?
- Budesonide (shown to reduce acute covid in RCT)
- Enovid nasal spray (pricey) or nasal flushing (also shown to reduce acute covid in RCT).
Logic -- anything that reduces severity/duration/viral load of acute covid likely to reduce risk of long covid, given viral load and severity correlate with risk long covid.
I have an alternate view on lung physiology that dismisses the notion of oxygen and carbon dioxide gaseous exchange
The article is titled
We breathe air not oxygen
I take you though all the steps that lead to this statement
Including how oxygen is manufactured
How oxygen is calibrated
Eg medical oxygen has 67parts per million of water contamination
Why oxygen is toxic, dehydrates and damages the alveoli
Lung physiology requires the air at the alveoli to reach 100% humidity
Can you see the problem?
The new take on lung physiology:
The lungs rehydrate the passing RBCs with iso tonic saline solution as they pass through the alveoli capillary beds
RBCs change from dark contracted dehydrated to plump bright hydrated form as they soak up the iso tonic saline solution the bursting alveoli bubbles throw upon the capillary sac
The airway mucosa conditions the breathe with salt and moisture
Seasonality of colds/flu is related to cold dry air and dehydration
Thank you so much for this. We just used this info to tailor a protocol for my partner and, so far (fingers crossed), his course was very very mild. Wondering about how long you’d recommend taking Nattokinase after the acute course has resolved?
Thank you for your time and labor; this article is pure gold and has helped me immensely!
Question: After a recent Covid infection, I started taking around 4-5mg of melatonin nightly. Around that time, I also experienced a 14-day menstrual cycle which has never happened before. It was heavy and exhausting. Would this have had anything to do with the high dose of melatonin, being that it’s a hormone?
We at my household (2 elderly with comorbidities) have had covid 3x and had a variety of symptoms, but used the same treatment and cleared symptoms between 24-48 hours after starting treatment. When preparing for covid in early 2020, I looked for an antiviral that was effective against single-stranded RNA viruses. Elderberry concentrate (EC) had been tested against influenza in several small RCTs and had been found to reduce symptom duration (and likely viral load by orders of magnitude) for at least 2 days. And EC contains a high conc. of quercetin. So that was our treatment for covid, along with calcifediol (active vit D metabolite), vit C, & zinc.
EC contains immune-boosting & immune-modulating flavonols, which is key for covid variants that suppress immune response. EC has been tested to elevate levels of tnf-alpha 45x !
My daughter, turning 3 in June, tested positive this morning. Her pediatrician’s office is of the opinion that long Covid doesn’t happen in children her age, and will not advise on any of the recommendations. For a family interested in benefiting from your work, but without access to a pediatrician willing to engage about Lactoferrin and otherwise, do you have recommendations? Thank you! -parent wanting to do anything possible to reduce risk of long Covid in child
Are you aware of ConsumerLabs.com, a phenomenal subscription resource for summaries of the literature on every imaginable supplement and evaluations by quality & brand of many products? Whenever a doctor suggests a supplement to me, it’s the first place I go.
If you don’t have access to it, could I gift you a one year subscription, which I think would be helpful in your research?
I am wondering if there'd be any significant changes to the protocol if one can't access paxlovid (E.g. use nattokinase from day 1?) Paxlovid is out of reach for most of us in Europe unfortunately. Also curious what you think of the claims that curcumin, quercetin resveratrol have 3CLpro-inhibition effects/can they be added when using this protocol?
Thanks once again for an amazing article. I had tried Lactoferrin previously for LC and thought I would try again after reading this. I split one Jarrow tablet contents into 2 does, had am dose mixed with lecithin and got mild gut issues. Had the other half dose before sleep, and unfortunately it worsened the adrenaline rush I get before sleep to the point I couldn't get to sleep til 3 am.(took at 10.30). Every time I got close to dropping off a surge would wake me up. This happens often but I can usually get past it with breathing exercises. I wonder why this would happen with the Lactoferrin? I also took ferrous sulphate an hour before and 2 Boluoke Lumbrokinase at same time. I also got mild gut pain with this dose too. Is this to be expected? Huge fan of your work and follow all your posts. Thank you so much for taking the time to write them.
What do you think of resveratrol?
https://www.nature.com/articles/s41598-022-13920-9
NAC
https://pubmed.ncbi.nlm.nih.gov/35084258/
OR
Niacin or other NAD precursors like nicotinamide riboside?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322475/
https://nkalex.medium.com/the-team-of-front-line-doctors-and-biohackers-who-seem-to-have-solved-long-covid-5f9852f1101d
https://www.nature.com/articles/s41418-020-0530-3
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202101222
https://www.nature.com/articles/s42255-021-00507-3
https://www.sciencedirect.com/science/article/pii/S1471490622000254
Thank you so much for this. Any thoughts on taking lactorrin, fish oil and nattokinase as a preventative measure when not positive for Covid?
Just to add a note:
Medications Associated with Lower Mortality in a SARS-CoV-2 Positive Cohort of 26,508 Veterans
https://link.springer.com/article/10.1007/s11606-022-07701-3
Key Results
The 26,508 SARS-CoV-2 positive patients were predominantly male (89%) and White (59%), and 82% were overweight/obese. Medications associated with decreased 30-day mortality risk included the following: metformin (aRR, 0.33; 95% CI, 0.25–0.43), colchicine, angiotensin-converting-enzyme inhibitors (ACEi), angiotensin II receptor blockers, statins, vitamin D, antihistamines, alpha-blockers, anti-androgens, and nonsteroidal anti-inflammatory drugs (aRR, 0.69; 95% CI, 0.61–0.78). The effect of co-prescribed medications on 30-day mortality risk revealed the lowest risk for combined statins and metformin (aRR, 0.21; 95% CI, 0.15–0.31), followed by ACEi and statins (aRR, 0.25; 95% CI, 0.18–0.35), ACEi and metformin (aRR, 0.26; 95% CI, 0.17–0.40), antihistamines and NSAIDs (aRR, 0.41; 95% CI, 0.32–0.52), and in men, combined alpha-blockers and anti-androgens (aRR, 0.51; 95% CI, 0.42–0.64).
Conclusions
In this large national cohort, treatment of SARS-CoV-2 positive patients with individual or co-prescribed metformin and statins, ACEi and statins (or metformin) and other medications was associated with a markedly decreased 30-day mortality and can likely be continued safely. Clinical trials may assess their therapeutic benefit.
Would taking famatodine reduce the effects on stomach acid on lactoferrin therefore increasing efficacy? I see this trial proposed the combination but I can’t find any articles on the outcome.
Wanted to know what you think about black seed oil capsules?
https://pubmed.ncbi.nlm.nih.gov/34407441/
this had some good results
Thank you for this detailed and extensive post. I would add one caveat. Diphenhydramine is anticholinergic. Its most dramatic potential side effects are more likely in older age groups. People age 65 and above are often advised not to take anticholingeric medications. That includes a great many antihistamines and decongestants. (I don't have your background. I know this only because it's why I had to reluctantly discontinue a daily antihistamine.)
This is excellent thanks. Any thoughts on extra suggestions below?
- Budesonide (shown to reduce acute covid in RCT)
- Enovid nasal spray (pricey) or nasal flushing (also shown to reduce acute covid in RCT).
Logic -- anything that reduces severity/duration/viral load of acute covid likely to reduce risk of long covid, given viral load and severity correlate with risk long covid.
I have an alternate view on lung physiology that dismisses the notion of oxygen and carbon dioxide gaseous exchange
The article is titled
We breathe air not oxygen
I take you though all the steps that lead to this statement
Including how oxygen is manufactured
How oxygen is calibrated
Eg medical oxygen has 67parts per million of water contamination
Why oxygen is toxic, dehydrates and damages the alveoli
Lung physiology requires the air at the alveoli to reach 100% humidity
Can you see the problem?
The new take on lung physiology:
The lungs rehydrate the passing RBCs with iso tonic saline solution as they pass through the alveoli capillary beds
RBCs change from dark contracted dehydrated to plump bright hydrated form as they soak up the iso tonic saline solution the bursting alveoli bubbles throw upon the capillary sac
The airway mucosa conditions the breathe with salt and moisture
Seasonality of colds/flu is related to cold dry air and dehydration
Dehydration is the point of susceptibility
Find the article
Jane333.Substack.com
Thank you so much for this. We just used this info to tailor a protocol for my partner and, so far (fingers crossed), his course was very very mild. Wondering about how long you’d recommend taking Nattokinase after the acute course has resolved?
Thank you for your time and labor; this article is pure gold and has helped me immensely!
Question: After a recent Covid infection, I started taking around 4-5mg of melatonin nightly. Around that time, I also experienced a 14-day menstrual cycle which has never happened before. It was heavy and exhausting. Would this have had anything to do with the high dose of melatonin, being that it’s a hormone?
We at my household (2 elderly with comorbidities) have had covid 3x and had a variety of symptoms, but used the same treatment and cleared symptoms between 24-48 hours after starting treatment. When preparing for covid in early 2020, I looked for an antiviral that was effective against single-stranded RNA viruses. Elderberry concentrate (EC) had been tested against influenza in several small RCTs and had been found to reduce symptom duration (and likely viral load by orders of magnitude) for at least 2 days. And EC contains a high conc. of quercetin. So that was our treatment for covid, along with calcifediol (active vit D metabolite), vit C, & zinc.
EC contains immune-boosting & immune-modulating flavonols, which is key for covid variants that suppress immune response. EC has been tested to elevate levels of tnf-alpha 45x !
My daughter, turning 3 in June, tested positive this morning. Her pediatrician’s office is of the opinion that long Covid doesn’t happen in children her age, and will not advise on any of the recommendations. For a family interested in benefiting from your work, but without access to a pediatrician willing to engage about Lactoferrin and otherwise, do you have recommendations? Thank you! -parent wanting to do anything possible to reduce risk of long Covid in child
Hello: is this a good protocol for a 7 year old. Please I’m desperate
1 hr before breakfast - 400 mg of lactoferrin in milk with drop of sunflower lecithin
Saline nasal rinse and cpc or reg mouthwash
With lunch EPA - 500 mg (consult ped)
With dinner - vit c and d
Bedtime - rinses plus melatonin