Are you aware of ConsumerLabs.com, a phenomenal subscription resource for summaries of the literature on every imaginable supplement and evaluations by quality & brand of many products? Whenever a doctor suggests a supplement to me, it’s the first place I go.
If you don’t have access to it, could I gift you a one year subscription, which I think would be helpful in your research?
I am wondering if there'd be any significant changes to the protocol if one can't access paxlovid (E.g. use nattokinase from day 1?) Paxlovid is out of reach for most of us in Europe unfortunately. Also curious what you think of the claims that curcumin, quercetin resveratrol have 3CLpro-inhibition effects/can they be added when using this protocol?
I did write about curcumin and resveratrol on Twitter.
Unfortunately they involve some drug interactions and it would be difficult to add them here. Bioavailability another concern. Dosing is also problematic with resveratrol. Would need to re-write everything. Plus I don't think they are as good as what I recommended.
I always try to mention Tollovid as an alternative. It's helped me significantly with LC and is claimed to have the same 3CL inhibiting mechanism as Pax does. But it's actually obtainable (if ordered ahead of time for acute infection).
Here in Australia, many doctors will refuse to prescribe Paxlovid. It costs > $1000 on private script and 5 day dosage is often not sufficient, as we've seen with the rebound effect.
* Nattokinase may be useful as a source of vitamin K2, once plentiful in the diet but now rare. K2 is available as a supplement combined with D3. Do not confuse this with K1, which promotes clotting!
* Melatonin is contraindicated in people with depressive disorders, and should not be taken for prolonged time periods lest it suppress the body's natural production. Most OTC formulas are too strong for nonmedicinal use.
* Valerian has a paradoxical effect on some people (I am one), producing insomnia instead of sleep.
* Antihistamines can leave one feeling unpleasantly groggy and stoned the next morning if more than a small dose is taken.
* Since Covid is notorious for causing severe blood clotting, any anticlotting agent (fish oil, aspirin or d-alpha vitamin E, could be of some benefit, *if* the patient is not on any prescription blood-thinner.
* I'm still waiting to find out about the impact of ACE-inhibitor blood pressure meds like Ramipril!
Would taking famatodine reduce the effects on stomach acid on lactoferrin therefore increasing efficacy? I see this trial proposed the combination but I can’t find any articles on the outcome.
Thanks once again for an amazing article. I had tried Lactoferrin previously for LC and thought I would try again after reading this. I split one Jarrow tablet contents into 2 does, had am dose mixed with lecithin and got mild gut issues. Had the other half dose before sleep, and unfortunately it worsened the adrenaline rush I get before sleep to the point I couldn't get to sleep til 3 am.(took at 10.30). Every time I got close to dropping off a surge would wake me up. This happens often but I can usually get past it with breathing exercises. I wonder why this would happen with the Lactoferrin? I also took ferrous sulphate an hour before and 2 Boluoke Lumbrokinase at same time. I also got mild gut pain with this dose too. Is this to be expected? Huge fan of your work and follow all your posts. Thank you so much for taking the time to write them.
Thanks for the links on potential treatments for covid. I like to look at the "Cited By" articles to see the latest studies, and I found this good summary for NAC, which cited the article you posted: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651994/ N-acetylcysteine for prevention and treatment of COVID-19: Current state of evidence and future directions
Hi! Big fan of your work. I’ve been novid for 3.5 years through the use of religiously using fitted N95 masks whenever indoors and even avoiding crowded outdoor spaces. Unfortunately my luck ran out this week during my anniversary vacation. Fortunately I got onto Paxlovid during the 2nd day of symptoms (including metformin on the 3rd day) but I am mostly concerned about microclots. I noticed your regimen to avoid long covid during acute phase does not include nattokinase while taking Paxlovid. Can you provide insight into why since I haven’t seen any contraindications online (in fact I see long covid sufferers trying the combo these days).
The 26,508 SARS-CoV-2 positive patients were predominantly male (89%) and White (59%), and 82% were overweight/obese. Medications associated with decreased 30-day mortality risk included the following: metformin (aRR, 0.33; 95% CI, 0.25–0.43), colchicine, angiotensin-converting-enzyme inhibitors (ACEi), angiotensin II receptor blockers, statins, vitamin D, antihistamines, alpha-blockers, anti-androgens, and nonsteroidal anti-inflammatory drugs (aRR, 0.69; 95% CI, 0.61–0.78). The effect of co-prescribed medications on 30-day mortality risk revealed the lowest risk for combined statins and metformin (aRR, 0.21; 95% CI, 0.15–0.31), followed by ACEi and statins (aRR, 0.25; 95% CI, 0.18–0.35), ACEi and metformin (aRR, 0.26; 95% CI, 0.17–0.40), antihistamines and NSAIDs (aRR, 0.41; 95% CI, 0.32–0.52), and in men, combined alpha-blockers and anti-androgens (aRR, 0.51; 95% CI, 0.42–0.64).
Conclusions
In this large national cohort, treatment of SARS-CoV-2 positive patients with individual or co-prescribed metformin and statins, ACEi and statins (or metformin) and other medications was associated with a markedly decreased 30-day mortality and can likely be continued safely. Clinical trials may assess their therapeutic benefit.
Thank you for this detailed and extensive post. I would add one caveat. Diphenhydramine is anticholinergic. Its most dramatic potential side effects are more likely in older age groups. People age 65 and above are often advised not to take anticholingeric medications. That includes a great many antihistamines and decongestants. (I don't have your background. I know this only because it's why I had to reluctantly discontinue a daily antihistamine.)
I am aware of this, yes. I was only presenting this as an option for those as a last resort if could not sleep. Risk benefit calculation. Will add a caveat about that.
This is excellent thanks. Any thoughts on extra suggestions below?
- Budesonide (shown to reduce acute covid in RCT)
- Enovid nasal spray (pricey) or nasal flushing (also shown to reduce acute covid in RCT).
Logic -- anything that reduces severity/duration/viral load of acute covid likely to reduce risk of long covid, given viral load and severity correlate with risk long covid.
I figured some would ask about Enovid. Thought about adding it but I think it works a lot better if a person uses it prophylactically. Once they realize they are ill, it may be too late for it to help much. I also didn't include it because it's not very accessible. But yeah, it's worth a shot and likely doesn't have serious drug interactions.
Not sure about budesonide -- I'll have to check out that trial. I'm guessing it helps people with cytokine storm but doesn't reduce viral load (?) so I'm not too high on that one.
Being using Enovid for 3 months now, i use it before entering high risk area (i also mask as much as i can with FFP3 respirator) and after coming home, so Twice a day.
or if i was unmasked (dentist,family dinner) 3-4 times a day.
it's not cheap so i chose how much to use it according to if i was able to mask in a situation or not.
Are you aware of ConsumerLabs.com, a phenomenal subscription resource for summaries of the literature on every imaginable supplement and evaluations by quality & brand of many products? Whenever a doctor suggests a supplement to me, it’s the first place I go.
If you don’t have access to it, could I gift you a one year subscription, which I think would be helpful in your research?
Yes, I'm a subscriber. :-)
I am wondering if there'd be any significant changes to the protocol if one can't access paxlovid (E.g. use nattokinase from day 1?) Paxlovid is out of reach for most of us in Europe unfortunately. Also curious what you think of the claims that curcumin, quercetin resveratrol have 3CLpro-inhibition effects/can they be added when using this protocol?
I did write about curcumin and resveratrol on Twitter.
Unfortunately they involve some drug interactions and it would be difficult to add them here. Bioavailability another concern. Dosing is also problematic with resveratrol. Would need to re-write everything. Plus I don't think they are as good as what I recommended.
Good question! If Pax unavailable you can start with Day 6.
I always try to mention Tollovid as an alternative. It's helped me significantly with LC and is claimed to have the same 3CL inhibiting mechanism as Pax does. But it's actually obtainable (if ordered ahead of time for acute infection).
Here in Australia, many doctors will refuse to prescribe Paxlovid. It costs > $1000 on private script and 5 day dosage is often not sufficient, as we've seen with the rebound effect.
Jesus, our government (canada) gave pharmacists the right to prescribe it and it costs next to nothing
* Nattokinase may be useful as a source of vitamin K2, once plentiful in the diet but now rare. K2 is available as a supplement combined with D3. Do not confuse this with K1, which promotes clotting!
* Melatonin is contraindicated in people with depressive disorders, and should not be taken for prolonged time periods lest it suppress the body's natural production. Most OTC formulas are too strong for nonmedicinal use.
* Valerian has a paradoxical effect on some people (I am one), producing insomnia instead of sleep.
* Antihistamines can leave one feeling unpleasantly groggy and stoned the next morning if more than a small dose is taken.
* Since Covid is notorious for causing severe blood clotting, any anticlotting agent (fish oil, aspirin or d-alpha vitamin E, could be of some benefit, *if* the patient is not on any prescription blood-thinner.
* I'm still waiting to find out about the impact of ACE-inhibitor blood pressure meds like Ramipril!
Thank you so much for this. Any thoughts on taking lactorrin, fish oil and nattokinase as a preventative measure when not positive for Covid?
Would taking famatodine reduce the effects on stomach acid on lactoferrin therefore increasing efficacy? I see this trial proposed the combination but I can’t find any articles on the outcome.
Thanks once again for an amazing article. I had tried Lactoferrin previously for LC and thought I would try again after reading this. I split one Jarrow tablet contents into 2 does, had am dose mixed with lecithin and got mild gut issues. Had the other half dose before sleep, and unfortunately it worsened the adrenaline rush I get before sleep to the point I couldn't get to sleep til 3 am.(took at 10.30). Every time I got close to dropping off a surge would wake me up. This happens often but I can usually get past it with breathing exercises. I wonder why this would happen with the Lactoferrin? I also took ferrous sulphate an hour before and 2 Boluoke Lumbrokinase at same time. I also got mild gut pain with this dose too. Is this to be expected? Huge fan of your work and follow all your posts. Thank you so much for taking the time to write them.
What do you think of resveratrol?
https://www.nature.com/articles/s41598-022-13920-9
NAC
https://pubmed.ncbi.nlm.nih.gov/35084258/
OR
Niacin or other NAD precursors like nicotinamide riboside?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322475/
https://nkalex.medium.com/the-team-of-front-line-doctors-and-biohackers-who-seem-to-have-solved-long-covid-5f9852f1101d
https://www.nature.com/articles/s41418-020-0530-3
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202101222
https://www.nature.com/articles/s42255-021-00507-3
https://www.sciencedirect.com/science/article/pii/S1471490622000254
I wrote about resveratrol here in a long thread:
https://twitter.com/organichemusic/status/1563070503342194690?s=20
Thanks for the links on potential treatments for covid. I like to look at the "Cited By" articles to see the latest studies, and I found this good summary for NAC, which cited the article you posted: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651994/ N-acetylcysteine for prevention and treatment of COVID-19: Current state of evidence and future directions
Is it ok to use NAC or mullein leaf when taking this protocol? Sorry, I might've posted already. Brain is foggy.
Hi! Big fan of your work. I’ve been novid for 3.5 years through the use of religiously using fitted N95 masks whenever indoors and even avoiding crowded outdoor spaces. Unfortunately my luck ran out this week during my anniversary vacation. Fortunately I got onto Paxlovid during the 2nd day of symptoms (including metformin on the 3rd day) but I am mostly concerned about microclots. I noticed your regimen to avoid long covid during acute phase does not include nattokinase while taking Paxlovid. Can you provide insight into why since I haven’t seen any contraindications online (in fact I see long covid sufferers trying the combo these days).
Many thanks!!!
Salt and sunshine made the difference for me. Saline nasal spray works wonders.
Just to add a note:
Medications Associated with Lower Mortality in a SARS-CoV-2 Positive Cohort of 26,508 Veterans
https://link.springer.com/article/10.1007/s11606-022-07701-3
Key Results
The 26,508 SARS-CoV-2 positive patients were predominantly male (89%) and White (59%), and 82% were overweight/obese. Medications associated with decreased 30-day mortality risk included the following: metformin (aRR, 0.33; 95% CI, 0.25–0.43), colchicine, angiotensin-converting-enzyme inhibitors (ACEi), angiotensin II receptor blockers, statins, vitamin D, antihistamines, alpha-blockers, anti-androgens, and nonsteroidal anti-inflammatory drugs (aRR, 0.69; 95% CI, 0.61–0.78). The effect of co-prescribed medications on 30-day mortality risk revealed the lowest risk for combined statins and metformin (aRR, 0.21; 95% CI, 0.15–0.31), followed by ACEi and statins (aRR, 0.25; 95% CI, 0.18–0.35), ACEi and metformin (aRR, 0.26; 95% CI, 0.17–0.40), antihistamines and NSAIDs (aRR, 0.41; 95% CI, 0.32–0.52), and in men, combined alpha-blockers and anti-androgens (aRR, 0.51; 95% CI, 0.42–0.64).
Conclusions
In this large national cohort, treatment of SARS-CoV-2 positive patients with individual or co-prescribed metformin and statins, ACEi and statins (or metformin) and other medications was associated with a markedly decreased 30-day mortality and can likely be continued safely. Clinical trials may assess their therapeutic benefit.
Wanted to know what you think about black seed oil capsules?
https://pubmed.ncbi.nlm.nih.gov/34407441/
this had some good results
I haven't looked into that enough yet to comment. Is that the same as black currant seed? I ask about it in my upcoming survey.
Thanks. so much for this. What is your opinion on using ivermectin with your suggestions? and the FLCCC protocol?
Thank you for this detailed and extensive post. I would add one caveat. Diphenhydramine is anticholinergic. Its most dramatic potential side effects are more likely in older age groups. People age 65 and above are often advised not to take anticholingeric medications. That includes a great many antihistamines and decongestants. (I don't have your background. I know this only because it's why I had to reluctantly discontinue a daily antihistamine.)
I am aware of this, yes. I was only presenting this as an option for those as a last resort if could not sleep. Risk benefit calculation. Will add a caveat about that.
Thank you. I really appreciate your posts.
It's updated. :)
This is excellent thanks. Any thoughts on extra suggestions below?
- Budesonide (shown to reduce acute covid in RCT)
- Enovid nasal spray (pricey) or nasal flushing (also shown to reduce acute covid in RCT).
Logic -- anything that reduces severity/duration/viral load of acute covid likely to reduce risk of long covid, given viral load and severity correlate with risk long covid.
I figured some would ask about Enovid. Thought about adding it but I think it works a lot better if a person uses it prophylactically. Once they realize they are ill, it may be too late for it to help much. I also didn't include it because it's not very accessible. But yeah, it's worth a shot and likely doesn't have serious drug interactions.
Not sure about budesonide -- I'll have to check out that trial. I'm guessing it helps people with cytokine storm but doesn't reduce viral load (?) so I'm not too high on that one.
What is best practice to use Enovid prophylactically? Use before going out and/or upon returning home?
Also, was curious to not see quercetin or curcumin on the list! Can I ask why not?
I just included my best picks based on my research.
I'll have to do a separate post on nasal sprays sometime. I'm working on a survey for sprays too.
Yes would love to hear about Azelastine as well! 🙂
Being using Enovid for 3 months now, i use it before entering high risk area (i also mask as much as i can with FFP3 respirator) and after coming home, so Twice a day.
or if i was unmasked (dentist,family dinner) 3-4 times a day.
it's not cheap so i chose how much to use it according to if i was able to mask in a situation or not.
Black seed is nigella, different from blackcurrant.